Modulation of Serum Inflammatory Pattern, Oxidative Stress, Selected Neurotransmitters in Cerebral Cortex of Alloxan Diabetic Rats: Role of Curcuminoids and Fish Oil as Therapeutic Agents

The current study aimed mainly to configurate any changes in selected neurotransmitters pattern, some inflammatory markers , oxidative stress in the brain of alloxan diabetic rats and to illustrate any relation between neurotransmitters activity and the inflammation degree . Effect of Fish oil and curcuminoids either individually or in association form were tested as neuroprotective agents. Materials and Methods: Fourty adult male western albino rats were rendered diabetic by alloxan administration ,then sub classified into five groups ,the first one received no drugs , served as diabetic control (DC) . The second one received Fish oil 50 mg /kgbody weight , the Third one received curcuminoids 50 mg/kg while the fourth one received Fish oil in association with curcuminoids daily for 60 days using the same doses used before. Another group of normal rats (10) was allocated , received no treatment and served as normal group. Results : Compared to normal group we have observed an increased level of MDA , serum IL-6 and CRP along with of GSH , DA , AchE and GABA decrease in the cerebral cortex of alloxan diabetic rats .Fish oil , curcuminoids either alone or in combination form have reversed these Biomarkers to certain degree.